Advancing Medical Care with Point-of-Care Diagnostics for Elevated Levels of Cell-free DNA
Abstract not provided.
Publications
FORENSICS OF ALGAL PRODUCTION POND CRASHES
Abstract not provided.
SpinDx: Portable Microfluidic Device for Pathogen & Biotoxin Diagnostics
Abstract not provided.
Pond Crash Forensics: rapid agent detection in open pond systems
Abstract not provided.
Rapid point-of-care diagnostic system for multi-parameter radiation biodosimetry using fingerstick whole blood
Proposed for publication in Nature Biotechnology.
Abstract not provided.
SpinDx: Rapid Radiation Biodosimetry
Abstract not provided.
SpinDx?: A Versatile Sensitive and Deployable Platform for Rapid Diagnostics of Emerging Diseases
Abstract not provided.
SpinDx: A Rapid Point-of-Care Biodosimetry Platform Using Peripheral Whole Blood Protein and Leukocyte Biomarkers
Abstract not provided.
SpinDx: A Rapid Point-of-Care Biodosimetry Platform
Abstract not provided.
Engineered Virus-Like Particles for Pathogen Detection Vaccination and Targeted Delivery of Therapeutics
Abstract not provided.
RAPID SENSITIVE DETECTION AND QUANTIFICATION OF TOXINS FROM COMPLEX BIOLOGICAL MATRICES
Abstract not provided.
Student Presentation: Automated instrumentation for analysis of centrifugal microfluidic discs
Abstract not provided.
Microfluidic Digital Isoelectric Fractionation for Rapid Multi-dimensional Glycoprotein Analysis
Proceedings of the National Academy of Sciences
Abstract not provided.
Rapid centrifugal proteomic and hematological assays for point-of-care radiation biodosimetry
Abstract not provided.
Rapid Sensitive Detection and Quantification of Toxins from Complex Biological Matrices
Abstract not provided.
Rapid biotoxin immunoassays and activity assays in a multiplexing chip
Abstract not provided.
Differential white cell count by centrifugal microfluidics
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
We present a method for counting white blood cells that is uniquely compatible with centrifugation based microfluidics. Blood is deposited on top of one or more layers of density media within a microfluidic disk. Spinning the disk causes the cell populations within whole blood to settle through the media, reaching an equilibrium based on the density of each cell type. Separation and fluorescence measurement of cell types stained with a DNA dye is demonstrated using this technique. The integrated signal from bands of fluorescent microspheres is shown to be proportional to their initial concentration in suspension.
Microscale isoelectric fractionation using immobilized ph-specific membranes for multi-dimensional analysis
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
We report on advancements of our microscale isoelectric fractionation (μIEFr) methodology for fast on-chip separation and concentration of proteins based on their isoelectric points (pI). We establish that proteins can be fractionated depending on posttranslational modifications into different pH specific bins, from where they can be efficiently transferred to downstream membranes for additional processing and analysis. This technology can enable on-chip multidimensional glycoproteomics analysis, as a new approach to expedite biomarker identification and verification.
Differential white cell count by centrifugal microfluidics
Abstract not provided.
Microscale isoelectric fractionation using immobilized pH-specific membranes for multi-dimensional analysis
We report on advancements of our microscale isoelectric fractionation ({mu}IEFr) methodology for fast on-chip separation and concentration of proteins based on their isoelectric points (pI). We establish that proteins can be fractionated depending on posttranslational modifications into different pH specific bins, from where they can be efficiently transferred to downstream membranes for additional processing and analysis. This technology can enable on-chip multidimensional glycoproteomics analysis, as a new approach to expedite biomarker identification and verification.
Rapid detection of botulinum neurotoxin A using an integrated microfluidic immunoassay platform
Abstract not provided.
Microfluidics for rapid radiation biodosimetry
Abstract not provided.
Microfluidic bioassays for rapid radiation dosimetry
Abstract not provided.
RAPID PORTABLE DIAGNOSTIC PLATFORM FOR TOXIN/PATHOGEN EXPOSURE SCENARIOS
Abstract not provided.
Rapid Automated Portable Infection/exposure/disease Dx (RAPIDx)
Abstract not provided.
Precise microscale polymer gradients applied to isoelectric focusing and pore limit electrophoresis
12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
We demonstrate the power of our technique for establishing and immobilizing well-defined polymer gradients in microchannels by fabricating two miniaturized analytical platforms: microscale immobilized pH gradients (μIPGs) for rapid and high resolution isoelectric focusing (IEF) applications, and polyacrylamide porosity gradients to achieve microscale pore limit electrophoresis (μPLE) in which species are separated based on molecular size by driving them toward the pore size at which migration ceases. Both separation techniques represent the first microscale implementation of their respective methodologies.
26 Results