Publications

Ultra-rapid sample preconcentration under slant field using high-aspect-ratio nanoporous membranes

Wang, Ying C.; Singh, Anup K.; Hatch, Anson H.

We describe a novel approach to fabricate high-aspect-ratio membranes in microchannels by direct laser scanning, and demonstrate >10-fold improvement in sample preconcentration speed by achieving lower fM detection of proteins within 5 minutes. The integrated device can be used for continuous sample preparation, injection, preconcentration, and biochemical binding/reaction applications. © 2008 CBMS.