Publications

Patch-clamp array with on-chip electronics, optics, flow control and mechanical actuation

Okandan, Murat O.; James, Conrad D.; Mani, Seethambal S.; Draper, Bruce L.

Fast and quantitative analysis of cellular activity, signaling and responses to external stimuli is a crucial capability and it has been the goal of several projects focusing on patch clamp measurements. To provide the maximum functionality and measurement options, we have developed a patch clamp array device that incorporates on-chip electronics, mechanical, optical and microfluidic coupling as well as cell localization through fluid flow. The preliminary design, which integrated microfluidics, electrodes and optical access, was fabricated and tested. In addition, new designs which further combine mechanical actuation, on-chip electronics and various electrode materials with the previous designs are currently being fabricated.