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Exploring a wider range of Mg-Ca-Zn metallic glass as biocompatible alloys using combinatorial sputtering

Li, Jinyang; Gittleson, Forrest S.; Liu, Yanhui; Liu, Jingbei; Loye, Ayomiposi M.; McMillon-Brown, Lyndsey; Kyriakides, Themis R.; Schroers, Jan; Taylor, André D.

In order to bypass the limitation of bulk metallic glasses fabrication, we synthesized thin film metallic glasses to study the corrosion characteristics of a wide atomic% composition range, Mg(35.9-63%)Ca(4.1-21%)Zn(17.9-58.3%), in simulated body fluid. We highlight a clear relationship between Zn content and corrosion current such that Zn-medium metallic glasses exhibit minimum corrosion. In addition, we found higher Zn content leads to a poor in vitro cell viability. These results showcase the benefit of evaluating a larger alloy compositional space to probe the limits of corrosion resistance and prescreen for biocompatible applications.