Publications

Centrifugal microfluidic platform for integrated analysis of proteins and nucleic acids from clinical and environmental samples

Koh, Chung-Yan K.; Phaneuf, C.R.; Light, Yooli K.; Mangadu, B.; Tran, Huu T.; Helm, J.I.; Throckmorton, Daniel J.; Singh, Anup K.

Portable, sensitive, easy-to-use diagnostics are urgently needed to meet the growing need for advanced healthcare in the developing world. As the recent outbreaks of infectious diseases have demonstrated, early detection and treatment are vital tools to containing outbreaks and minimizing loss of life. Toward addressing these concerns, we have developed a centrifugal microfluidic platform capable of detecting both proteins and nucleic acids signatures from biological threats. This platform utilizes a novel sedimentation assay format to integrate sample preparation into a single step. Platform performance is competitive with traditional benchtop techniques.