Tessily Hogancamp

Postdoctoral Appointee

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Postdoctoral Appointee

tnhogan@sandia.gov

(505) 284-3264

Sandia National Laboratories, New Mexico
 P.O. Box 5800
 Albuquerque, NM 87185-1363

Biography

Tessily Hogancamp’s research focuses on developing genetic tools in non-model organisms that have the potential to produce competitively priced bioproducts and biofuels. Specifically, the goal is to optimize RNA interference (RNAi) and CRISPR interference (CRISPRi) in the oleaginous yeast Rhodosporidium toruloides for gene knockdown to increase the carbon flux to relevant biosynthesized beachhead molecules, like bisabolene, a jet fuel precursor. Emerging microbial hosts, like R. toruloides that naturally has a high production of lipids, are advantageous compared to model organisms like Saccharomyces cerevisiae when implementing a scale-up production in a sustainable bioeconomy. This work will contribute additional genetic tools that can be used for the metabolic engineering of R. toruloides.

Education

Bachelor’s Degree: Biology and Chemistry, The University of Tennessee at Chattanooga (2007-2012) Advisor: Dr. Steven Symes

Doctoral Degree: Chemistry, Texas A&M University, College Station (2014-2019) Advisor: Dr. Frank M. Raushel

Postdoctoral Appointee: Sandia National Laboratories (2020-Present) Advisor: Anne M. Ruffing

Hogancamp’s dissertation investigated the enzymatic mechanisms utilized during the bacterial degradation of lignin in the protocatechuate 4,5-cleavage pathway. She elucidated the mechanistic details of LigU isomerase, LigJ hydratase, and LigK aldolase using proton and carbon NMR spectroscopy, site-directed mutagenesis, X-ray crystallography, and steady-state kinetics.

Publications

Tessily Hogancamp, (2020). Developing RNA Interference in Rhodotorula toruloides for Gene Knockdown https://www.osti.gov/servlets/purl/1835001 Publication ID: 72091

Tessily Hogancamp, Anne Ruffing, John Gladden, (2020). Developing RNA Interference in Rhodotorula toruloides for Gene Knockdown https://doi.org/10.2172/1837621 Publication ID: 72363

Tessily Hogancamp, Anne Ruffing, John Gladden, (2020). Developing RNA Interference in Rhodotorula toruloides for Gene Knockdown https://doi.org/10.2172/1837801 Publication ID: 72382

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Selected Publications
  • Hogancamp, T.N., Cory, S.A., Barondeau, D.P., and Raushel, F.M. (2019) Structure and Chemical Reaction Mechanism of LigU, an Enzyme that Catalyzes an Allylic Isomerization in the Bacterial Degradation of Lignin. Biochemistry 58, 3494-3503.
  • Hogancamp, T.N., Mabanglo, M.F., and Raushel, F.M. (2018) Structure and Reaction Mechanism of the LigJ Hydratase: An Enzyme Critical for the Bacterial Degradation of Lignin in the Protocatechuate 4,5-Cleavage Pathway. Biochemistry 57, 5841-5850.
  • Hogancamp, T.N. and Raushel, F.M. (2018) Functional Annotation of LigU as a 1,3-Allylic Isomerase During the Degradation of Lignin in the Protocatechuate 4,5-Cleavage Pathway from the Soil Bacterium Sphingomonas paucimobilis SKY-6. Biochemistry 57, 2837-2845.
Honors and Awards
  • Sandia Spot Award for COVID diagnostic lab effort, Sandia National Laboratories, 2021
  • Sandia Spot Award for Excellence in COVID diagnostic lab support, Sandia National Laboratories, 2020
  • I. Scott Medal Symposium Best Poster, Texas A&M University, 2019 (out of 42 recipients)
  • ACS Division of Biological Chemistry Travel Award, 26th Enzyme Mechanisms Conference, New Orleans, LA, 2019
  • Derek and Christine Barton Graduate Endowment for Organic Chemistry, Texas A&M University, 2018
  • Runner-up for 21st Annual Student Research Week Poster Presentation in Graduate Sciences Division, Texas A&M University, 2018